Ananth Hari

Computational Postdoctoral Fellow
College Park, US.

About

Highly accomplished PhD candidate in Computer Engineering with extensive expertise in computational biology, genomics, and machine learning, currently completing a Predoctoral Visiting Fellowship at the National Cancer Institute (NIH). Proven ability to develop advanced computational frameworks and algorithms for complex biological data, including single-cell and spatial genomics, DNA methylation, and whole exome sequencing, with a strong publication record. Eager to apply innovative computational methods to investigate tumor cell plasticity and therapeutic resistance within the Chan Lab at Memorial Sloan Kettering Cancer Center, contributing to impactful translational oncology research.

Work

National Cancer Institute, NIH
|

Predoctoral Visiting Fellow

Bethesda, MD, US

Summary

Leading advanced computational biology research at the intersection of genomics and cancer, developing novel algorithms and frameworks for analyzing complex biological data.

Highlights

Developed and deployed a novel computational framework for precise genotyping and copy number analysis of Immunoglobulin Heavy Chain Variable genes using short-read sequencing data, significantly advancing immunogenomics research.

Enhanced existing pharmacogenes genotyping tools by integrating additional genes of interest, significantly expanding the scope and utility for genetic analysis in cancer research.

Designed and co-implemented an iterative algorithm to infer brain cell development profiles and quantify cell type proportions within glioblastoma patient samples, leveraging DNA methylation data to reveal cellular heterogeneity.

Conducted in-depth computational analysis of MAIT cell roles in glioblastoma, contributing to understanding immune evasion mechanisms and potential therapeutic targets in tumor microenvironments.

Contributed to the scientific community as a reviewer for prestigious conferences including ACM-BCB, RECOMB, and ECCB/ISMB, ensuring high standards of research dissemination in computational biology.

National Cancer Institute, NIH
|

Summer Intern

Bethesda, MD, US

Summary

Implemented a machine learning classifier to differentiate tumor types, contributing to early-stage cancer diagnostics research.

Highlights

Developed and validated a machine learning classifier to accurately differentiate between two distinct tumor types based on whole exome sequencing data, enhancing diagnostic capabilities for cancer research.

University of Maryland, College Park
|

Teaching Assistant - Parallel Algorithms

College Park, MD, US

Summary

Supported the instruction of parallel algorithms, helping students grasp advanced computational methods.

Highlights

Assisted in the delivery of course content on parallel algorithms, translating complex topics into understandable concepts for students.

Evaluated assignments and provided constructive feedback, contributing to student understanding and skill development in parallel computing.

University of Maryland, College Park
|

Teaching Assistant - Digital Computer Design

College Park, MD, US

Summary

Supported students in digital computer design, fostering practical skills in logic and circuit implementation.

Highlights

Guided students through digital logic design and circuit implementation, facilitating hands-on learning and project completion.

Offered expert assistance during design exercises and debugging sessions, improving student proficiency in digital systems.

University of Maryland, College Park
|

Teaching Assistant - Math. Foundations For Comp. Engg.

College Park, MD, US

Summary

Provided instructional support and mentorship to undergraduate students in foundational computer engineering mathematics.

Highlights

Guided students through complex mathematical concepts and problem-solving techniques, improving comprehension and academic performance.

Facilitated weekly discussion sections and office hours, offering personalized assistance and reinforcing course material for diverse student groups.

University of Maryland, College Park
|

Teaching Assistant - Computer Organization

College Park, MD, US

Summary

Assisted in teaching computer organization principles, enhancing student understanding of hardware-software interaction.

Highlights

Clarified intricate concepts of computer architecture and organization, enabling students to grasp fundamental system design principles.

Provided practical support for laboratory sessions and project work, ensuring students successfully applied theoretical knowledge.

University of Maryland, College Park
|

Teaching Assistant - Parallel Algorithms

College Park, MD, US

Summary

Supported the instruction of parallel algorithms, helping students grasp advanced computational methods.

Highlights

Assisted in the delivery of course content on parallel algorithms, translating complex topics into understandable concepts for students.

Evaluated assignments and provided constructive feedback, contributing to student understanding and skill development in parallel computing.

University of Maryland, College Park
|

Teaching Assistant - Math. Foundations For Comp. Engg.

College Park, MD, US

Summary

Provided instructional support and mentorship to undergraduate students in foundational computer engineering mathematics.

Highlights

Guided students through complex mathematical concepts and problem-solving techniques, improving comprehension and academic performance.

Facilitated weekly discussion sections and office hours, offering personalized assistance and reinforcing course material for diverse student groups.

Samsung R&D Institute India
|

Senior Software Engineer, Memory Controller Division

Bengaluru, Karnataka, India

Summary

Led software development initiatives within the Memory Controller Division, focusing on enhancing system performance and reliability for advanced semiconductor products.

Highlights

Optimized memory controller algorithms, contributing to significant improvements in data processing efficiency and system throughput.

Collaborated with cross-functional engineering teams to design and implement robust software solutions for next-generation memory architectures.

Contributed to the full software development lifecycle, from requirements gathering and design to testing and deployment, ensuring high-quality product delivery.

Samsung R&D Institute India
|

Intern

Noida, Uttar Pradesh, India

Summary

Supported software development projects, gaining foundational experience in industrial research and development.

Highlights

Assisted in the development and testing of software components for memory controller systems, ensuring adherence to project specifications.

Contributed to documentation and preliminary analysis tasks, supporting senior engineers in project execution.

Volunteer

University of Maryland, College Park
|

Member, ECE Graduate Student Association

College Park, MD, United States of America

Summary

Actively participated in the Electrical and Computer Engineering Graduate Student Association, contributing to the graduate student community.

Highlights

Engaged in initiatives to foster a supportive and collaborative environment for graduate students within the ECE department.

Contributed to organizing academic and social events, enhancing student life and professional networking opportunities.

University of Maryland, College Park
|

Member, UMD Table Tennis Coed team

College Park, MD, United States of America

Summary

Participated as a member of the University of Maryland Table Tennis Coed team, promoting teamwork and athletic engagement.

Highlights

Represented the university in coed table tennis competitions, demonstrating sportsmanship and dedication.

Contributed to team cohesion and skill development through regular practice and collaborative play.

Education

University of Maryland, College Park
College Park, MD, United States of America

PhD

Computer Engineering

University of Maryland, College Park
College Park, MD, United States of America

Masters

Computer Engineering

Indian Institute of Technology - Madras
Chennai, Tamil Nadu, India

Bachelors and Masters

Electrical Engineering

Awards

UMD 'Year of Data Science' Summer Fellowship

Awarded By

University of Maryland, College Park

Recognized for outstanding potential and contributions in data science, supporting advanced research initiatives.

Dean's Fellow

Awarded By

University of Maryland, College Park

Awarded for exceptional academic achievement and scholarly promise within the university's graduate program.

Publications

Characterization of MAIT cells in glioblastoma reveals a potential immunosuppressive role through a MAIT-Neutrophil axis

Published by

Neuro-Oncology Advances

Summary

Investigated the immunosuppressive functions of MAIT cells in glioblastoma, identifying their role through a MAIT-Neutrophil axis.

Elucidating developmental methylation programs and cell type compositions in glioblastoma using combinatorial optimization

Published by

Cancer Research

Summary

Applied combinatorial optimization to DNA methylation data to elucidate developmental programs and cell type compositions in glioblastoma.

Biologically-informed killer cell immunoglobulin-like receptor gene annotation tool

Published by

Bioinformatics

Summary

Developed a biologically-informed tool for annotating killer cell immunoglobulin-like receptor genes, enhancing immunogenomic analysis.

Empirical Challenge for NC Theory

Published by

Proceedings of the 2023 ACM Workshop on Highlights of Parallel Computing

Summary

Presented an empirical challenge for NC Theory, contributing to the understanding of parallel computing complexities.

An efficient genotyper and star-allele caller for pharmacogenomics

Published by

Genome Research

Summary

Developed an efficient genotyper and star-allele caller specifically designed for pharmacogenomics applications.

ImmunoTyper-SR: A computational approach for genotyping immunoglobulin heavy chain variable genes using short-read data

Published by

Cell systems

Summary

Introduced ImmunoTyper-SR, a computational method for genotyping immunoglobulin heavy chain variable genes from short-read data.

ImmunoTyper-SR: A Novel Computational Approach for Genotyping Immunoglobulin Heavy Chain Variable Genes using Short Read Data

Published by

RECOMB. Springer

Summary

Presented ImmunoTyper-SR, a novel computational approach for genotyping immunoglobulin heavy chain variable genes using short-read data.

Pettingzoo: Gym for multi-agent reinforcement learning

Published by

Advances in Neural Information Processing Systems

Summary

Introduced Pettingzoo, a Gym-compatible library for multi-agent reinforcement learning environments.

Revisiting parameter sharing in multi-agent deep reinforcement learning

Published by

arXiv preprint

Summary

Explored parameter sharing strategies in multi-agent deep reinforcement learning, published online.

Agent environment cycle games

Published by

arXiv preprint

Summary

Investigated agent environment cycle games within reinforcement learning, published online.

Supersuit: Simple microwrappers for reinforcement learning environments

Published by

arXiv preprint

Summary

Developed Supersuit, a collection of simple microwrappers to facilitate reinforcement learning environment development, published online.

Languages

English

Skills

Programming Languages

Python, C, XMTC.

Tools & Systems

LaTeX, SLURM, Bash.

Computational Biology & Bioinformatics

Genomics, Single-Cell Genomics, Spatial Genomics, DNA Methylation Analysis, Whole Exome Sequencing, Immunogenomics, Cancer Research, Tumor Cell Plasticity, Lineage Plasticity.

Data Analysis & Machine Learning

Machine Learning, Algorithm Development, Statistical Analysis, Multi-modal Data Integration, Predictive Modeling, Classifier Development.

Scientific & Academic Skills

Scientific Writing, Peer Review, Academic Mentorship, Research Methodology.